Follicular Lymphoma with Widespread Skin Lesions and Chromosome 14;18 Translocation in the Skin


Vincent C. Ho,* Ali Almofadhi,† and Victor A. Tron†

Abstract

Background: We report a case of systemic follicular B-cell lymphoma presenting with widespread skin lesions.

Objective: The clinical features, histology, and treatment of primary and secondary cutaneous follicular lymphomas are discussed.

Conclusion: The demonstration of chromosome 14;18 translocation in the skin that is commonly found in primary, but rare in secondary, cutaneous follicular lymphoma can be helpful in confirming the diagnosis.

Sommaire

Antécédents: Observation d’un cas de lymphome malin folliculaire systémique à cellules B se manifestant par des lésions cutanées étendues.

Objectif: Examiner les manifestations cliniques, l’histologie et le traitement des lymphomes cutanés primitifs et secondaires.

Conclusion: Établir la preuve de la translocation dans la peau du chromosome 14;18, qui est fréquente dans les lymphomes cutanés primitifs et rare dans les lymphomes cutanés secondaires, peut être utile pour confirmer le diagnostic.


Received 10/30/96. Accepted for publication 4/14/97.

*Division of Dermatology and †Department of Pathology, University of British Columbia, Vancouver Hospital and Health Sciences Centre, and the British Columbia Cancer Agency, Vancouver, British Columbia

Reprints are not available from the author.

Address for correspondence: Vincent Ho, MD, Division of Dermatology, University of British Columbia, 835 W. 10th Avenue, Vancouver, BC V5Z 4E8

Full text available in the print edition / Pour le texte intégral veuillez consulter la version imprimée.


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